N.F.L. Week 1 Predictions: Our Picks Against the Spread

Bills at Jets, 1 p.m., CBS

Line: Jets -3. Total: 40.5.

The Jets got themselves a Peyton Manning-approved head coach, Adam Gase, to try to unlock the immense promise in Sam Darnold’s arm. They also scored Le’Veon Bell, a superstar running back, in free agency after Bell’s holdout (and eventual exit) last season with Pittsburgh. The seeds seem to be there for a breakout season, but don’t overlook the Bills. They saw what Josh Allen, the team’s young quarterback, does best — throw the ball deep — and they got him a pair of wide receivers (John Brown and Cole Beasley) who can take advantage of that. In Week 1, however, Allen will have to restrain himself or else Gregg Williams, the Jets’ hyperaggressive defensive coordinator, will make him pay for any mistakes. Pick: Jets -3

Falcons at Vikings, 1 p.m., Fox

Line: Vikings -4. Total: 48.

In Minnesota’s third preseason game this year, Dalvin Cook, the team’s third-year running back, showed why the team should be excited for his return. He was not expected to even play in his team’s eventual win over Arizona, but the Vikings decided to give him two carries, and on one of them he broke a tackle and ran for an 85-yard touchdown. A formidable run game could ease the pressure on Kirk Cousins and get Minnesota back where it thought it would be last season. Pick: Vikings -4

Redskins at Eagles, 1 p.m., Fox

Line: Eagles -10. Total: 45.

Case Keenum is fine. He’s not the long-term solution at quarterback for Washington — Dwayne Haskins has that role — but Keenum, when allowed some freedom to play to his own strengths, is decidedly fine. That, combined with a team that was actually fairly plucky before Alex Smith’s season-ending injury last year, could make Washington far more formidable than it might seem at a glance. In an opening week with a few curiously large spreads, this one stands out as perhaps the most aggressive. Pick: Redskins +10

Bengals at Seahawks, 4:05 p.m., CBS

Line: Seahawks -9.5. Total: 44.

There’s plenty of reason to believe that Coach Zac Taylor has something special about him and that he can modernize a stagnant Bengals approach. After all, he’s one of just four head coaches in the N.F.L. who got there without having first been an offensive or defensive coordinator at the pro level. But is Andy Dalton the quarterback to run the type of frantic play-action offense that Taylor will presumably have brought over from the Rams? A road game in Seattle seems like a terrible time to find out. Seattle should win, but covering such a wide spread is far from a given. Pick: Bengals +9.5